Development of new material coatings based on hybrid Au@Ag nanostars and PVDF for biocide applications The widespread use of antibiotics is generating the appearance of multiresistant microorganisms, which will become one of the most dangerous hazards for human health in the next years. Physical methods with biocidal properties are appearing as a promising alternative to mitigate this problem. [1, 2, 3] Here, several versions of silver-coated gold nanostars (Au@Ag NSs) were synthesized through seed-mediated growth processes, generating partially coated nanostars exhibiting Au tips that protrude from the silver coatings. They…

MODULAR MICROPUMPS FABRICATED BY 3D PRINTED TECHNOLOGIES Yara Alvarez-Braña1,2, Fernando Benito-Lopez2,3,4,* and Lourdes Basabe-Desmonts1,3,4,5,* 1Microfluidics Cluster UPV/EHU, BIOMICs microfluidics Group, Vitoria-Gasteiz, Spain. 2Microfluidics Cluster UPV/EHU, Analytical Microsystems & Materials for Lab-on-a-Chip (AMMa-LOAC), University of the Basque Country UPV/EHU, Spain. 3Bioaraba Health Research Institute, Vitoria-Gasteiz, Spain. 4BCMaterials, Basque Center for Materials, Applications and Nanostructures, Leioa, Spain. 5Basque Foundation of Science, IKERBASQUE, Spain. ABSTRACT In order to facilitate the implementation of self-powered microfluidic technology for rapid point-of-care analysis, the modular architecture of degas driven polymeric micropumps assembled with microfluidic cartridges arose during…

ALGINATE BEAD BIOSENSORS FOR THE DETERMINATION OF LACTATE LEVELS USING IMAGE ANALYSIS Sandra Garcia-Rey1,2, Edilberto Ojeda1,2, Udara Bimendra Gunatilakea,b, Lourdes Basabe-Desmonts2,3,4,5,*, and Fernando Benito-Lopez1,2,3,* 1Microfluidics Cluster UPV/EHU, Analytical Microsystems & Materials for Lab-on-a-Chip (AMMa-LOAC) Group, Analytical Chemistry Department, University of the Basque Country UPV/EHU, Spain 2Microfluidics Cluster UPV/EHU, BIOMICs microfluidics Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain 3Bioaraba Health Research Institute, Microfluidics Cluster UPV/EHU, Vitoria-Gasteiz, Spain 4BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, Leioa, Spain 5Basque Foundation of Science, IKERBASQUE, María…

IONOGEL BASED MATERIAL FOR THE COLORIMETRIC DETECTION OF Δ9-TETRAHYDROCANNABINOL Raquel Catalan-Carrio1, Guillermo Moreno-Sanz2, Lourdes Basabe-Desmonts1,3,4,5,*, Fernando Benito-Lopez1,3,4,* 1Microfluidics Cluster UPV/EHU, University of the Basque Country UPV/EHU, Spain 2ABAGUNE RESEARCH, Vitoria-Gasteiz, Spain 3Bioaraba Health Research Institute, Vitoria-Gasteiz, Spain 4BCMaterials, Basque Centre for Materials, Micro and Nanodevices, UPV/EHU Science Park, Leioa, Spain 5Basque Foundation for Science, IKERBASQUE, Spain {raquel.catalan, lourdes.basabe, fernando.benito}@ehu.eus ABSTRACT Cannabis sativa is the most widely abused illegal drug in the world. Additionally, there is an increasing interest in the production of non-psychoactive industrial hemp for several applications, including the…

MICROFLUIDIC DEVICE FOR THE DYNAMIC CHARACTERIZATION OF CELL ADHESION USING SINGLE CELL ADHESION DOT ARRAYS (SCADA) ABSTRACT Cell affinity to certain substrates is of great importance for a wide range of applications. One way to quantify it is to analyze single cell arrays as digital indicators of adhesion to the substrate by the presence or absence of cell on a dot. So far, this methodology –Single Cell Adhesion Dot Array or SCADA– has only been exploited on conventional culture plates, whose use restricts time resolution and requires large amounts of…

Development of biomimetic tympanic membrane substitutes for the treatment of chronic perforations Ainhoa Irastorza1, Carlos Chiesa2, Ander Izeta1*, Pedro Guerrero3*, Koro de la Caba3* 1 Biodonostia Health Research Institute, Tissue Engineering Group 2 Donostia University Hospital, Department of Otorhinolaryngology-Head and Neck Surgery 3 University of the Basque Country (UPV/EHU), BIOMAT Research Group * ander.izeta@biodonostia.org, pedromanuel.guerrero@ehu.eus, koro.delacaba@ehu.eus Perforation of the tympanic membrane (PTM) is a common cause of consultation in Otolaryngology, due to infections or trauma. The rate of recovery from perforation depends mainly on the size of the perforation and…

ZIF-8 Nanoparticle synthesis via Microfluidics: Dean flow impact on particle size Xiangjiang Yu Poster In this poster, I will show the effect of secondary parameters in the microfluidic setups, in particular how the coiling of the tube and its relation to the flow rates and different reactor geometries, on particle synthesis. First we discussed the flow patterns in different tubes. Then the dean numbers for different setups were established, and the size, size distribution, and morphology of particles obtained under different reactor geometries were evaluated to fine-tune these characteristics. I…

Hybrid multifunctional bioinks for 3D printed disease models Uxue Aizarna Lopetegui1, Luis Liz-Marzán1,2,3, Malou Henriksen-Lacey1,2, Dorleta Jimenez de Aberasturi1,2,3 1 CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo de Miramón 182, Donostia-San Sebastián 20014, Spain. 2Ciber-BBN, 20014 Donostia-San Sebastián, Spain; 3Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain 3D printing and nanotechnology have emerged as promising tools that contribute to advancing biomedical research, including the fabrication of complex in vitro tissue models that can give us further insight into cancer progression1,2. Organic-inorganic hybrid materials, composed of different polymers or…

TiO2 Nanotubes Alginate Hydrogel Scaffold for Rapid Sensing of Sweat Biomarkers – Lactate and Glucose Udara Bimendra Gunatilake1,2, Sandra Garcia-Rey1,2, Edilberto Ojeda1,2, Lourdes Basabe-Desmonts2,3,4* Fernando Benito-Lopez1,4* 1Analytical Microsystems & Materials for Lab-on-a-Chip (AMMa-LOAC) Group, Microfluidics Cluster UPV/EHU, University of the Basque Country UPV/EHU, Spain. 2BIOMICs microfluidics Research Group, Microfluidics Cluster UPV/EHU, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain. 3Basque Foundation of Science, IKERBASQUE, Spain. 4BCMaterials, Basque Center for Materials, Applications and Nanostructures, Spain. ABSTRACT Versatile sensing matrixes are essential for the development of enzyme immobilised optical…

3D PRINTING OF PEDOT:PSS CONDUCTIVE POLYMER BY DIGITAL LIGHT PROCESSING FOR APPLICATION IN BIOELECTRONICS Naroa Lopez-Larrea1, Miryam Criado-Gonzalez1, Bastien Marchiori2, Isabel del Agua2, Antonio Dominguez-Alfaro1, Nuria Alegret1 and David Mecerreyes1,3 1 POLYMAT University of the Basque Country UPV/EHU, Avenida de Tolosa 72, 20018 Donostia-San Sebastián, Spain 2 Panaxium SAS, Aix-en-Provence 13100, France 3 Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain Email: naroa.lopez@polymat.eu, david.mecerreyes@ehu.es Conducting polymers (CPs) such as poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS), polypyrrole (PPy) or polyaniline (PANi) have been attracting increased interest for the development of several (bio-opto)electronic and energy…

Bioelectronic capture and release of cancer cells Janire Saez1,2,3*, Maite Garcia-Hernando2,4, Achilleas Savva1, Lourdes Basabe-Desmonts2,3, Fernando Benito-Lopez4*and Róisín M. Owens1 1 Department of Chemical Engineering and Biotechnology, University of Cambridge, U.K. 2 Microfluidics Cluster UPV/EHU, BIOMICs microfluidics Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Spain 3 Basque Foundation of Science, IKERBASQUE, Spain 4 Microfluidics Cluster UPV/EHU, Analytical Microsystems & Materials for Lab-on-a-Chip (AMMa-LOAC) Group, Analytical Chemistry Department, University of the Basque Country UPV/EHU, Spain. ABSTRACT Here, we present a novel thermo-responsive material, poly(N-isopropylacrylamide) combined with an electroactive…

Continous monitoring of cell transfection efficiency on micropatterned substrates Conventional cell cultures lack control over cell interactions and usually require detachment of the cells for the quantification of gene transfection efficiency. In order to study the effect of cell-cell contact on the efficiency of transfection, we applied micropatterning of mesenchymal stromal cells to generate two different cell-cell contact scenarios, one of single cells and one of small cell-colonies, Figure 1, through microcontact printing in order to study the effect of cell-cell contact on the transfection efficiency.

Water ethanol based sprayed photovoltaic solar cells Chalcogenides materials have ideal properties as light absorber materials to fulfil the next generation of large production photovoltaics. They are composed of abundant raw materials, with low toxicity, high stability, can be synthesized at low to moderate temperatures, and required low film thickness to work efficiently. Developing a superstrate architecture, based on an FTO/TiO2 electrode, allows new ways of engineering the formation of the thin film. This is in line with the motivation of reducing the use of scarce elements, while at the…

Magnetorheological elastomers as multifuctional materials for biomedical devices and applications Magnetorheological elastomers (MREs) are activa materials composed of a polymeric matrix and an inorganic magnetic filler. Their rheological and mechanical characteristics can be actuated remotely by using a magnetic field. Thus, they are highly interesting for biomedical applications in which power delivery to several devices could be a limiting factor, including medical tools such as stents or catheters. Further, they are compatible with additive manufacturing techniques, which renders the fabrication process much more convenient. In this work, we focus on…